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|Section2= |Section3= }} Zinc protoporphyrin (ZPP) is a compound found in red blood cells when heme production is inhibited by lead and/or by lack of iron. Instead of incorporating a ferrous ion, to form heme, protoporphyrin IX, the immediate precursor of heme, incorporates a zinc ion, forming ZPP. The reaction to insert a ferrous ion into protoporphyrin IX is catalyzed by the enzyme ferrochelatase. ==Clinical utility== Measurement of zinc protoporphyrin in red cells has been used as a ''screening'' test for lead poisoning. and for iron deficiency. There are a number of specific clinical situations in which this measurement has been found to be useful.〔 Zinc protoporphyrin levels can be elevated as the result of a number of conditions, for instance:〔 *lead poisoning *iron deficiency *sickle cell anemia *sideroblastic anemia *anemia of chronic disease *vanadium exposure *erythropoietic protoporphyria〔http://beaunet.beaumont.edu/portal/pls/portal/lab.lab_pkg.lab_test_info_content?xid=862〕 The virtue of ZPP testing as a ''screen'' is that all of these conditions can be considered worth discovering. The fluorescent properties of ZPP in intact red cells allows the ZPP/heme molar ratio to be measured quickly, at low cost, and in a small sample volume. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Zinc protoporphyrin」の詳細全文を読む スポンサード リンク
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